Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

The association between rheumatoid arthritis (RA) and periodontal disease (PD) has been
the focus of numerous investigations driven by their common pathological features. RA is an …

The most specific autoimmunity known for rheumatoid arthritis (Ra) is reflected by
generation of anti-citrullinated protein antibodies (acPa). Presence of acPa in established …

The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs
following tissue damage remain unclear. Using a virus-induced model of autoantibody …

Emerging data implicate the microbiome in RA pathogenesis. Mucosal sites exposed to a
high load of bacterial antigens–such as the periodontium, lung, and gut–may represent the …

Objectives An increased prevalence of periodontitis and perturbation of the oral microbiome
has been identified in patients with rheumatoid arthritis (RA). The periodontal pathogen …

Importance The prevalence of periodontitis is increased in patients with rheumatoid arthritis
(RA) and periodontopathic bacteria can citrullinate proteins. Periodontitis may, therefore, be …

Investigations are needed to determine when and where RA begins, including
comprehensive prospective studies of individuals in the preclinical period of RA that can …

Objective To investigate the role of genetic and environmental factors in the development of
anticitrullinated protein antibodies (ACPA) and ACPA-positive rheumatoid arthritis (RA) in a …

Established and emerging data demonstrate that a'preclinical'period of disease precedes
the onset of clinical rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as …