[HTML][HTML] Epigenetic mechanisms of postoperative cognitive impairment induced by anesthesia and neuroinflammation

K Rump, M Adamzik - Cells, 2022 - mdpi.com
Cognitive impairment after surgery is a common problem, affects mainly the elderly, and can
be divided into postoperative delirium and postoperative cognitive dysfunction. Both …

Postoperative neurocognitive disorders

C Olotu - Current Opinion in Anesthesiology, 2020 - journals.lww.com
Postoperative neurocognitive disorders are frequent complications, especially in elderly
patients, with postoperative delirium being its most pronounced and acute postoperative …

Postoperative delirium and postoperative cognitive dysfunction: overlap and divergence

LA Daiello, AM Racine, RY Gou… - …, 2019 - pmc.ncbi.nlm.nih.gov
Background: Postoperative delirium and postoperative cognitive dysfunction share risk
factors and may co-occur, but their relationship is not well-established. The primary goals of …

Postoperative cognitive dysfunction in older surgical patients associated with increased healthcare utilization: a prospective study from an upper-middle-income …

P Suraarunsumrit, C Pathonsmith, V Srinonprasert… - BMC geriatrics, 2022 - Springer
Background Perioperative neurocognitive disorder includes postoperative cognitive
dysfunction (POCD) and postoperative delirium (POD). Concerning inconclusive …

Postoperative cognitive dysfunction: a concept analysis

HA Varpaei, K Farhadi, M Mohammadi… - Aging Clinical and …, 2024 - Springer
Background Post-operative cognitive dysfunction (POCD) is a concern for clinicians that
often presents post-surgery where generalized anesthesia has been used. Its prevalence …

Dexmedetomidine ameliorates postoperative cognitive dysfunction via the microRNA-381-mediated EGR1/p53 axis

YL Wang, Y Zhang, DS Cai - Molecular Neurobiology, 2021 - Springer
Postoperative cognitive dysfunction (POCD; cognitive change associated with anesthesia
and surgery) is one of the most serious long-term postoperative complications that occur in …

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers

M Berger, JN Browndyke… - Annals of clinical …, 2022 - Wiley Online Library
Objective Numerous investigators have theorized that postoperative changes in Alzheimer's
disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we …

Depth of anesthesia monitoring: An argument for its use for patient safety

K Brook, AV Agarwala, F Li… - Current Opinion in …, 2024 - journals.lww.com
There is evidence that DoA monitoring may decrease the incidence of awareness,
postoperative delirium, POCD and improve several postoperative outcomes. In children …

The effect of delirium preventive measures on the occurrence of postoperative cognitive dysfunction in older adults undergoing cardiovascular surgery. The DelPOCD …

C Olotu, L Ascone, J Wiede, J Manthey, S Kuehn… - Journal of Clinical …, 2022 - Elsevier
Study objective This trial examines the effect of delirium preventive measures on the
incidence of postoperative cognitive dysfunction in older adults. Design In a randomised …

Effects of dexmedetomidine on cognitive dysfunction and neuroinflammation via the HDAC2/HIF‐1α/PFKFB3 axis in a murine model of postoperative cognitive …

YF Liu, R Hu, LF Zhang, Y Fan… - Journal of Biochemical …, 2022 - Wiley Online Library
Inhibition of histone deacetylase (HDAC) may be a useful approach in the treatment of
disorders characterized by cognitive dysfunction. Dexmedetomidine (DEX), an α2 …