Reappraising the value of HIV-1 vaccine correlates of protection analyses
PJ Klasse, JP Moore - Journal of Virology, 2022 - Am Soc Microbiol
With the much-debated exception of the modestly reduced acquisition reported for the
RV144 efficacy trial, HIV-1 vaccines have not protected humans against infection, and a …
RV144 efficacy trial, HIV-1 vaccines have not protected humans against infection, and a …
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
Uninfected bystander cells impact the measurement of HIV-specific antibody-dependent cellular cytotoxicity responses
The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody
recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence …
recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence …
The HIV latency reversal agent HODHBt enhances NK cell effector and memory-like functions by increasing interleukin-15-mediated STAT activation
Elimination of human immunodeficiency virus (HIV) reservoirs is a critical endpoint to
eradicate HIV. One therapeutic intervention against latent HIV is “shock and kill.” This …
eradicate HIV. One therapeutic intervention against latent HIV is “shock and kill.” This …
Incomplete downregulation of CD4 expression affects HIV-1 Env conformation and antibody-dependent cellular cytotoxicity responses
ABSTRACT HIV-1-infected cells expressing envelope glycoproteins (Env) in the CD4-bound
conformation on their surfaces are targeted by antibody-dependent cellular cytotoxicity …
conformation on their surfaces are targeted by antibody-dependent cellular cytotoxicity …
HIV-1-specific IgA monoclonal antibodies from an HIV-1 vaccinee mediate galactosylceramide blocking and phagocytosis
S Wills, KK Hwang, P Liu, SM Dennison… - Journal of …, 2018 - Am Soc Microbiol
Vaccine-elicited humoral immune responses comprise an array of antibody forms and
specificities, with only a fraction contributing to protective host immunity. Elucidation of …
specificities, with only a fraction contributing to protective host immunity. Elucidation of …
Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single Infected CD4+ T …
ABSTRACT The HIV-1 Nef and Vpu accessory proteins are known to protect infected cells
from antibody-dependent cellular cytotoxicity (ADCC) responses by limiting exposure of …
from antibody-dependent cellular cytotoxicity (ADCC) responses by limiting exposure of …
An engineered vaccine of the Plasmodium vivax Duffy binding protein enhances induction of broadly neutralizing antibodies
Plasmodium vivax invasion into human reticulocytes is a complex process. The Duffy
binding protein (DBP) dimerization with its cognate receptor is vital for junction formation in …
binding protein (DBP) dimerization with its cognate receptor is vital for junction formation in …
Bridging vaccine-induced HIV-1 neutralizing and effector antibody responses in rabbit and rhesus macaque animal models
J Pollara, DI Jones, T Huffman, RW Edwards… - Journal of …, 2019 - Am Soc Microbiol
Studies in animal models are essential prerequisites for clinical trials of candidate HIV
vaccines. Small animals, such as rabbits, are used to evaluate promising strategies prior to …
vaccines. Small animals, such as rabbits, are used to evaluate promising strategies prior to …
A trimeric HIV-1 envelope gp120 immunogen induces potent and broad anti-V1V2 loop antibodies against HIV-1 in rabbits and rhesus macaques
ABSTRACT Trimeric HIV-1 envelope (Env) immunogens are attractive due to their ability to
display quaternary epitopes targeted by broadly neutralizing antibodies (bNAbs) while …
display quaternary epitopes targeted by broadly neutralizing antibodies (bNAbs) while …