The collection of components required to carry out the intricate processes involved in
generating and maintaining a living, breathing and, sometimes, thinking organism is …

Next-generation sequencing technologies are now being exploited not only to analyse static
genomes, but also dynamic transcriptomes in an approach termed RNA-seq. Although these …

We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

Topologically associating domains (TADs), CTCF loop domains, and A/B compartments
have been identified as important structural and functional components of 3D chromatin …

Post-transcriptional gene regulation frequently occurs through elements in mRNA 3′
untranslated regions (UTRs),. Although crucial roles for 3′ UTR-mediated gene regulation …

Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people
in develo** countries. Amongst the human-infective species, Schistosoma mansoni is also …

Understanding the dynamics of eukaryotic transcriptome is essential for studying the
complexity of transcriptional regulation and its impact on phenotype. However …

A recently developed technique called RNA Sequencing (RNA‐Seq) uses massively
parallel sequencing to allow transcriptome analyses of genomes at a far higher resolution …

Background Until recently, chromosomal translocations and fusion genes have been an
underappreciated class of mutations in solid tumors. Next-generation sequencing …

Cellular efficiency in protein translation is an important fitness determinant in rapidly growing
organisms. It is widely believed that synonymous codons are translated with unequal …