Molecular mechanism of azithromycin resistance among typhoidal Salmonella strains in Bangladesh identified through passive pediatric surveillance
Background With the rise in fluoroquinolone-resistant Salmonella Typhi and the recent
emergence of ceftriaxone resistance, azithromycin is one of the last oral drugs available …
emergence of ceftriaxone resistance, azithromycin is one of the last oral drugs available …
Parallel evolution of tobramycin resistance across species and environments
Different species exposed to a common stress may adapt by mutations in shared pathways
or in unique systems, depending on how past environments have molded their genomes …
or in unique systems, depending on how past environments have molded their genomes …
MarA, RamA, and SoxS as mediators of the stress response: survival at a cost
To survive and adapt to changing environments, bacteria have evolved mechanisms to
express appropriate genes at appropriate times. Exposure to antimicrobials triggers a global …
express appropriate genes at appropriate times. Exposure to antimicrobials triggers a global …
Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles
Antibiotic resistance is a pressing healthcare challenge and is mediated by various
mechanisms, including the active export of drugs via multidrug efflux systems, which prevent …
mechanisms, including the active export of drugs via multidrug efflux systems, which prevent …
[HTML][HTML] Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella
RM Johnson, C Fais, M Parmar, H Cheruvara… - Microorganisms, 2020 - mdpi.com
Salmonella is an important genus of Gram-negative pathogens, treatment of which has
become problematic due to increases in antimicrobial resistance. This is partly attributable to …
become problematic due to increases in antimicrobial resistance. This is partly attributable to …
Massively parallel transposon mutagenesis identifies temporally essential genes for biofilm formation in Escherichia coli
Biofilms complete a life cycle where cells aggregate, grow and produce a structured
community before dispersing to colonize new environments. Progression through this life …
community before dispersing to colonize new environments. Progression through this life …
Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella
Cephalosporins are important beta lactam antibiotics, but resistance can be mediated by
various mechanisms including production of beta lactamase enzymes, changes in …
various mechanisms including production of beta lactamase enzymes, changes in …
From acute to persistent infection: revealing phylogenomic variations in Salmonella Agona
Salmonella enterica serovar Agona (S. Agona) has been increasingly recognised as a
prominent cause of gastroenteritis. This serovar is a strong biofilm former that can undergo …
prominent cause of gastroenteritis. This serovar is a strong biofilm former that can undergo …
Donor plasmids for phenotypically neutral chromosomal gene insertions in Enterobacteriaceae
Recombineering using bacteriophage lambda Red recombinase (λ-Red) uses homologous
recombination to manipulate bacterial genomes and is commonly applied to disrupt genes …
recombination to manipulate bacterial genomes and is commonly applied to disrupt genes …
Experimental evolution to identify undescribed mechanisms of resistance to a novel cationic peptide antibiotic
A Santos-Lopez, MJ Fritz, JB Lombardo, AHP Burr… - bioRxiv, 2020 - biorxiv.org
A key strategy for resolving the antibiotic resistance crisis is the development of new drugs
with antimicrobial properties. The engineered cationic antimicrobial peptide WLBU2 (also …
with antimicrobial properties. The engineered cationic antimicrobial peptide WLBU2 (also …