Dementia prevention, intervention, and care

G Livingston, A Sommerlad, V Orgeta, SG Costafreda… - The lancet, 2017 - thelancet.com
Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …

Alzheimer's disease

P Scheltens, K Blennow, MMB Breteler, B De Strooper… - The Lancet, 2016 - thelancet.com
Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Diagnosis of early Alzheimer's disease: clinical practice in 2021

AP Porsteinsson, RS Isaacson, S Knox… - The journal of …, 2021 - Springer
Alzheimer's disease is a progressive, irreversible neurodegenerative disease impacting
cognition, function, and behavior. Alzheimer's disease progresses along a continuum from …

Assessment and management of behavioral and psychological symptoms of dementia

HC Kales, LN Gitlin, CG Lyketsos - Bmj, 2015 - bmj.com
Behavioral and psychological symptoms of dementia include agitation, depression, apathy,
repetitive questioning, psychosis, aggression, sleep problems, wandering, and a variety of …

Alzheimer's disease drug development pipeline: 2020

J Cummings, G Lee, A Ritter… - … research & clinical …, 2020 - Wiley Online Library
Introduction Alzheimer's disease (AD) is a growing public health concern affecting millions of
patients worldwide and costing billions of dollars annually. We review the pipeline of drugs …

Alzheimer's disease

CL Masters, R Bateman, K Blennow… - Nature reviews disease …, 2015 - nature.com
Alzheimer's disease is a chronic illness with long preclinical and prodromal phases (20
years) and an average clinical duration of 8–10 years. The disease has an estimated …

Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities

Z Ismail, B Creese, D Aarsland, HC Kales… - Nature Reviews …, 2022 - nature.com
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment

Z Ismail, EE Smith, Y Geda, D Sultzer, H Brodaty… - Alzheimer's & …, 2016 - Elsevier
Neuropsychiatric symptoms (NPS) are common in dementia and in predementia syndromes
such as mild cognitive impairment (MCI). NPS in MCI confer a greater risk for conversion to …

Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm

DT Maust, HM Kim, LS Seyfried, C Chiang… - JAMA …, 2015 - jamanetwork.com
Importance Antipsychotic medications are associated with increased mortality in older adults
with dementia, yet their absolute effect on risk relative to no treatment or an alternative …