Photodynamic therapy for skin cancer: How to enhance drug penetration?

M Champeau, S Vignoud, L Mortier… - Journal of Photochemistry …, 2019 - Elsevier
Photodynamic therapy (PDT) induced by protoporphyrin IX (PpIX) has been widely used in
dermatological practices such as treatment of skin cancers. Clearance rate depends on …

Conversion of levulinic acid to valuable chemicals: a review

WP Xu, XF Chen, HJ Guo, HL Li… - Journal of Chemical …, 2021 - Wiley Online Library
Levulinic acid (LA), a class of important chemical intermediates and new energy chemicals,
has been considered one of the top‐12 platform compounds that can be converted from …

An intelligent transdermal formulation of ALA‐loaded copolymer thermogel with spontaneous asymmetry by using temperature‐induced sol–gel transition and gel–sol …

D Cao, X Chen, F Cao, W Guo, J Tang… - Advanced Functional …, 2021 - Wiley Online Library
Aqueous solutions of some amphiphilic block copolymers undergo a sol–gel transition upon
heating and are thus called thermogels. In the thermogel family, some systems also exhibit a …

5‐Aminolevulinic acid‐loaded hyaluronic acid dissolving microneedles for effective photodynamic therapy of superficial tumors with enhanced long‐term stability

J Zhu, L Dong, H Du, J Mao, Y **e… - Advanced …, 2019 - Wiley Online Library
Aminolevulinic acid (5‐ALA) is one of the most widely used prodrug in clinical photodynamic
therapy of dermatological diseases and cancers; yet, its clinical application is still limited by …

Enhancement of topical 5‐aminolaevulinic acid delivery by erbium: YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation

JY Fang, WR Lee, SC Shen, YP Fang… - British Journal of …, 2004 - academic.oup.com
Summary Background 5‐aminolaevulinic acid (ALA) is used as a protoporphyrin IX‐
precursor for the photodynamic therapy of superficial skin cancer and cutaneous metastases …

Systematic review and meta-analysis of in vitro anti-human cancer experiments investigating the use of 5-aminolevulinic acid (5-ALA) for photodynamic therapy

Y Shinoda, D Kato, R Ando, H Endo, T Takahashi… - Pharmaceuticals, 2021 - mdpi.com
5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin
IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis …

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

KM Tewari, IM Eggleston - Photochemical & Photobiological Sciences, 2018 - pubs.rsc.org
The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels
of endogenous porphyrins is currently one of the most important approaches for …

Nanocarriers in topical photodynamic therapy

N Dragicevic, J Predic-Atkinson, B Nikolic… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Photodynamic therapy (PDT) has gained significant attention due to its
superiority over conventional treatments. In the context of skin cancers and nonmalignant …

A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid

M Champeau, D Jary, L Mortier, S Mordon… - International Journal of …, 2020 - Elsevier
Photodynamic therapy induced by protoporphyrin IX (PpIX) is widely used to treat
precancerous skin lesions. The penetration depth of the prodrug 5-aminolevulinic acid (5 …

Challenges and opportunities of bioprocessing 5-aminolevulinic acid using genetic and metabolic engineering: a critical review

YC Yi, IT Shih, TH Yu, YJ Lee, IS Ng - Bioresources and Bioprocessing, 2021 - Springer
Aminolevulinic acid (5-ALA), a non-proteinogenic five-carbon amino acid, has received
intensive attentions in medicine due to its approval by the US Food and Drug Administration …