Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Background Cardiovascular disease (CVD) has been the leading cause of death worldwide
for many years. In recent years, exosomes have gained extensive attention in the …

Utilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle
arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision …

Zebrafish and mammalian neonates possess robust cardiac regeneration via the induction
of endogenous cardiomyocyte (CM) proliferation, but adult mammalian hearts have very …

Background: Few effective therapies exist to improve lower extremity muscle pathology and
mobility loss due to peripheral artery disease (PAD), in part because mechanisms …

BACKGROUND: The importance of mitochondria in normal heart function are well
recognized and recent studies have implicated changes in mitochondrial metabolism with …

Rationale: Most current cardiac regeneration approaches result in very limited cell division
and little new cardiomyocyte (CM) mass. Positive feedback loops are vital for cell division …

Cardiovascular diseases are the leading cause of death worldwide. Cardiomyocytes are
capable of coordinated contractions, which are mainly responsible for pum** blood. When …

Acute myocardial infarction (MI), despite significant progress in its treatment, remains a
leading cause of chronic heart failure and cardiovascular events such as cardiac arrest …

Fully restoring the lost population of cardiomyocytes and heart function remains the greatest
challenge in cardiac repair post myocardial infarction. In this study, a pioneered highly ROS …