Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …

Foods high in carbohydrates are an important part of a healthy diet, since they provide the
body with glucose to support bodily functions and physical activity. However, the abusive …

The metabolic characteristics of tumors present considerable hurdles to immune cell
function and cancer immunotherapy. Using a glutamine antagonist, we metabolically …

Brain metastases are refractory to therapies that control systemic disease in patients with
human epidermal growth factor receptor 2-positive breast cancer and the brain …

Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

The tumor microenvironment (TME) is a unique metabolic niche that can inhibit T cell
metabolism and cytotoxicity. To dissect the metabolic interplay between tumors and T cells …

Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …

Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …