Covert and overt hepatic encephalopathy: diagnosis and management

KR Patidar, JS Bajaj - Clinical Gastroenterology and Hepatology, 2015 - Elsevier
Hepatic encephalopathy (HE) is part of a spectrum of neurocognitive changes in cirrhosis.
HE is divided into 2 broad categories based on severity: covert hepatic encephalopathy …

Hepatic encephalopathy: a critical current review

A Hadjihambi, N Arias, M Sheikh, R Jalan - Hepatology international, 2018 - Springer
Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of cirrhosis and/or
porto-systemic shunting. The clinical symptoms are widely variable, extending from subtle …

[PDF][PDF] Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European …

H Vilstrup, P Amodio, J Bajaj, J Cordoba… - …, 2014 - Wiley Online Library
They selected references within their field of expertise and experience and graded the
references according to the GRADE system. 1 The selection of references for the guideline …

Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy

JS Bajaj, DM Heuman, AJ Sanyal, PB Hylemon… - PloS one, 2013 - journals.plos.org
Hepatic encephalopathy (HE) represents a dysfunctional gut-liver-brain axis in cirrhosis
which can negatively impact outcomes. This altered gut-brain relationship has been treated …

Impaired gut-liver-brain axis in patients with cirrhosis

V Ahluwalia, NS Betrapally, PB Hylemon, MB White… - Scientific reports, 2016 - nature.com
Cirrhosis is associated with brain dysfunction known as hepatic encephalopathy (HE). The
mechanisms behind HE are unclear although hyperammonemia and systemic inflammation …

The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers

JS Bajaj, JB Wade, DP Gibson… - Official journal of the …, 2011 - journals.lww.com
OBJECTIVES: Cirrhosis and hepatic encephalopathy (HE) can adversely affect survival, but
their effect on socioeconomic and emotional burden on the family is not clear. The aim was …

Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites

G Dam, H Vilstrup, H Watson, P Jepsen - Hepatology, 2016 - journals.lww.com
Proton pump inhibitors (PPIs) may be a risk factor for hepatic encephalopathy (HE) in
patients with cirrhosis, possibly through translocation of gut bacteria, which can also lead to …

Non‐absorbable disaccharides versus placebo/no intervention and lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with …

LL Gluud, H Vilstrup… - Cochrane Database of …, 2016 - cochranelibrary.com
Background Non‐absorbable disaccharides (lactulose and lactitol) are recommended as
first‐line treatment for hepatic encephalopathy. The previous (second) version of this review …

the design of clinical trials in hepatic encephalopathy–an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement

JS Bajaj, J Cordoba, KD Mullen… - Alimentary …, 2011 - Wiley Online Library
Aliment Pharmacol Ther 2011; 33: 739–747 Summary Background The clinical classification
of hepatic encephalopathy is largely subjective, which has led to difficulties in designing …

[HTML][HTML] The link between gut microbiota and hepatic encephalopathy

SM Won, KK Oh, H Gupta, R Ganesan… - International journal of …, 2022 - mdpi.com
Hepatic encephalopathy (HE) is a serious complication of cirrhosis that causes
neuropsychiatric problems, such as cognitive dysfunction and movement disorders. The link …