Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

Observations from different brain areas have established that the adult nervous system can
undergo significant experience-related structural changes throughout life. Less familiar is …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation. Here,
we provide evidence that brain swelling triggers Ca2+ signaling in astrocytes and that …

The volume-regulated anion channel (VRAC), also known as the volume-sensitive
outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion …

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by
chronic white matter oedema. The disease has an infantile onset and leads to slow …

The volume‐regulated anion channel (VRAC) plays a pivotal role in cell volume regulation
in essentially all cell types studied. Additionally, VRAC appears to contribute importantly to a …

During brain and spinal cord development, GABA and glycine, the inhibitory
neurotransmitters, cause depolarization instead of hyperpolarization in adults. Since glycine …

Abstract d-Serine is thought to be a glia-derived transmitter that activates N-methyl d-
aspartate receptors (NMDARs) in the brain. Here, we investigate the pathways for d-serine …

Over the last decade, a series of studies has demonstrated that glia in the central nervous
system play roles in many aspects of neuronal functioning including pain processing …