Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative
disorders. These diseases are normally characterized by progressive loss of neuron cells …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

The primary cause of Huntington's disease (HD) is expression of huntingtin with a
polyglutamine expansion. Despite an absence of consensus on the mechanism (s) of …

Adult neurogenesis is limited to specific brain regions in the mammalian brain, such as the
hippocampal dentate gyrus and the subventricular zone/olfactory bulb system. Alterations in …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Objective Although the underlying cause of Huntington's disease (HD) is well established,
the actual pathophysiological processes involved remain to be fully elucidated. In other …

Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's
disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a …

Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type
but not mutant huntingtin stimulates transcription of the gene encoding brain-derived …

Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the
gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein …