The role of the blood–brain barrier during neurological disease and infection

A Patabendige, D Janigro - Biochemical Society Transactions, 2023 - portlandpress.com
A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the
endothelial cells that line brain capillaries. The BBB plays an extremely important role in …

Blood–brain barrier transporters: opportunities for therapeutic development in ischemic stroke

KL Nilles, EI Williams, RD Betterton, TP Davis… - International Journal of …, 2022 - mdpi.com
Globally, stroke is a leading cause of death and long-term disability. Over the past decades,
several efforts have attempted to discover new drugs or repurpose existing therapeutics to …

Hypertension: causes and consequences of circadian rhythms in blood pressure

FM Faraci, FAJL Scheer - Circulation Research, 2024 - Am Heart Assoc
Hypertension is extremely common, affecting approximately 1 in every 2 adults globally.
Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and …

Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood–Brain Barrier Crossing Ability

Q Song, J Li, T Li, HW Li - Advanced Science, 2024 - Wiley Online Library
As a form of dementia, Alzheimer's disease (AD) suffers from no efficacious cure, yet AD
treatment is still imperative, as it ameliorates the symptoms or prevents it from deteriorating …

Circulating cardiac biomarkers, structural brain changes, and dementia: Emerging insights and perspectives

M Jensen, T Zeller, R Twerenbold… - Alzheimer's & …, 2023 - Wiley Online Library
Diseases of the heart and brain are strongly linked to each other, and cardiac dysfunction is
associated with cognitive decline and dementia. This link between cardiovascular disease …

The impact of blood pressure variability on the development of parenchymal hematoma in acute cerebral infarction with atrial fibrillation

MN Wu, YP Liu, YO Fong, YH Lin, IH Yang… - Hypertension …, 2024 - nature.com
Although blood pressure variability (BPV) and reperfusion are associated with parenchymal
hematoma (PH) after stroke, the relationship between BPV and PH in atrial fibrillation (AF) …

The impact of atrial fibrillation treatment strategies on cognitive function

N Bodagh, I Kotadia, A Gharaviri, F Zelaya… - Journal of Clinical …, 2023 - mdpi.com
There is increasing evidence to suggest that atrial fibrillation is associated with a heightened
risk of dementia. The mechanism of interaction is unclear. Atrial fibrillation-induced cerebral …

Heart–brain interaction in cardiogenic dementia: pathophysiology and therapeutic potential

J Liu, G **ao, Y Liang, S He, M Lyu… - Frontiers in Cardiovascular …, 2024 - frontiersin.org
Diagnosis and treatment of patients with cardiovascular and neurologic diseases primarily
focus on the heart and brain, respectively. An increasing number of preclinical and clinical …

The role of atrial fibrillation in vascular cognitive impairment and dementia: Epidemiology, pathophysiology, and preventive strategies

M Fekete, EM Liotta, T Molnar, GA Fülöp, A Lehoczki - GeroScience, 2024 - Springer
The aging population in Europe faces a substantial burden from dementia, with vascular
cognitive impairment and dementia (VCID) being a preventable cause. Atrial fibrillation (AF) …

Trajectory of Cardiogenic Dementia: A New Perspective

N AlRawili, HM Al‐Kuraishy… - Journal of Cellular …, 2025 - Wiley Online Library
The functions of the heart and brain are closely linked and essential to support human life by
the heart‐brain axis, which is a complex interconnection between the heart and brain. Also …