Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

[HTML][HTML] The role of SOX family members in solid tumours and metastasis

D Grimm, J Bauer, P Wise, M Krüger… - Seminars in cancer …, 2020 - Elsevier
Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

The cardiovascular system in space: focus on in vivo and in vitro studies

R Baran, S Marchal, S Garcia Campos, E Rehnberg… - Biomedicines, 2021 - mdpi.com
On Earth, humans are subjected to a gravitational force that has been an important
determinant in human evolution and function. During spaceflight, astronauts are subjected to …

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

D Grimm, M Wehland, TJ Corydon… - Stem cells …, 2020 - academic.oup.com
A spaceflight has enormous influence on the health of space voyagers due to the combined
effects of microgravity and cosmic radiation. Known effects of microgravity (μ g) on cells are …

[HTML][HTML] Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells

MZ Nassef, S Kopp, M Wehland, D Melnik… - International journal of …, 2019 - mdpi.com
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

Small tissue chips with big opportunities for space medicine

X Mu, W He, VAM Rivera, RAD De Alba… - Life sciences in space …, 2022 - Elsevier
The spaceflight environment, including microgravity and radiation, may have considerable
effects on the health and performance of astronauts, especially for long-duration and Martian …

Biomanufacturing of 3D tissue constructs in microgravity and their applications in human pathophysiological studies

Z Ren, AD Harriot, DB Mair, MK Chung… - Advanced …, 2023 - Wiley Online Library
The growing interest in bioengineering in‐vivo‐like 3D functional tissues has led to novel
approaches to the biomanufacturing process as well as expanded applications for these …

[HTML][HTML] The effects of microgravity on the digestive system and the new insights it brings to the life sciences

JQ Yang, N Jiang, ZP Li, S Guo, ZY Chen, BB Li… - Life sciences in space …, 2020 - Elsevier
BACKGROUND: Weightlessness is a component of the complex space environment. It
exerts adverse effects on the human body, and may pose unknown challenges to the …

Recent progress in space physiology and aging

F Strollo, S Gentile, G Strollo, A Mambro… - Frontiers in …, 2018 - frontiersin.org
Astronauts coming back from long-term space missions present with different health
problems potentially affecting mission performance, involving all functional systems and …

Growth factor gene-modified mesenchymal stem cells in tissue regeneration

WB Nie, D Zhang, LS Wang - Drug Design, Development and …, 2020 - Taylor & Francis
There have been marked changes in the field of stem cell therapeutics in recent years, with
many clinical trials having been conducted to date in an effort to treat myriad diseases …