Atherosclerotic disease, such as myocardial infarction and stroke, is the number one killer
worldwide. Atherosclerosis is considered to be caused by multiple factors, including genetic …

Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Atherosclerosis is a chronic inflammatory vascular disease and the predominant cause of
heart attack and ischemic stroke. Despite the well-known sexual dimorphism in the …

The development of CETP (cholesteryl ester transfer protein) inhibitors has had a long and
difficult course with 3 compounds failing in phase III clinical trials. Finally, the REVEAL …

One of the earliest and best-recognized elements of atherosclerosis is its close relationship
with circulating LDL (low-density lipoprotein). There is convincing evidence that LDL …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Abstract Purpose of Review Elevated high-density lipoprotein cholesterol levels in the blood
(HDL-C) represent one of the strongest epidemiological surrogates for protection against …

Abstract Purpose of Review To provide perspective on the current development status, and
potential future role, of obicetrapib, a third-generation cholesterylester transfer protein …

Rabbits are one of the most used experimental animals for biomedical research, particularly
as a bioreactor for the production of antibodies. However, many unique features of the rabbit …

Abstract Matrix metalloproteinase‐9 (MMP‐9), or gelatinase B, has been hypothesized to be
involved in the progression of atherosclerosis. In the arterial wall, accumulated …