Glioblastoma (GBM) is one of the deadliest types of cancer and highly refractory to
chemoradiation and immunotherapy. One of the main reasons for this resistance to therapy …

Malignant tumors have increasing morbidity and high mortality, and their occurrence and
development is a complicate process. The development of sequencing technologies …

Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics,
spatial proteomics, and computational approaches to define glioma cellular states and …

Intratumor heterogeneity underlies cancer evolution and treatment resistance, but targetable
mechanisms driving intratumor heterogeneity are poorly understood. Meningiomas are the …

Glioblastoma, the most aggressive primary brain cancer, has a dismal prognosis, yet
systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies …

Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

The evolutionary trajectory of glioblastoma (GBM) is a multifaceted biological process that
extends beyond genetic alterations alone. Here, we perform an integrative proteogenomic …

Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of
maximal surgical tumor resection, accompanied by chemotherapy and radiotherapy …

Glioblastoma multiforme (GBM) is the most common and malignant type of primary brain
tumor in adults. Despite important advances in understanding the molecular pathogenesis …