The pulmonary route has long been used for drug administration for both local and systemic
treatment. It possesses several advantages, which can be categorized into physiological, ie …

Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma
and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked …

With the rapidly growing popularity and sophistication of inhalation therapy, there is an
increasing demand for tailor-made inhalable drug particles capable of affording the most …

Polymorphism of drug substances has been the subject of intense investigation in the
pharmaceutical field for over 40 years. Considering the multitude of reports on solubility or …

The appearance and disappearance of polymorphs is no longer a mysterious and
inexplicable process. Although methods for polymorph control are still imperfect, there is a …

Supercritical fluids possess the unique properties of behaving like liquids and gases, above
their critical point. Supercritical fluid technology has recently emerged as a green and novel …

Here we review the polymorphism of organic molecules, obtained through batch
crystallization in solution carried out in a stirred vessel. Preferential formation of a …

Many years of research have not led to a profound knowledge of the mechanisms involved
in the formulation and dispersion of carrier based mixtures for inhalation. Although it is well …

Solid-state, crystallographic purity and careful monitoring of the polymorphism of drugs and
excipients are currently an integral part of the development of modern drug delivery systems …

Supercritical fluid (SCF) techniques for materials precipitation have been the subject of
many studies, mostly with the intention of making highly uniform particles. The SCF process …