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p21 in cancer: intricate networks and multiple activities
T Abbas, A Dutta - Nature Reviews Cancer, 2009 - nature.com
One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …
Senescence in wound repair: emerging strategies to target chronic healing wounds
Cellular senescence is a fundamental stress response that restrains tumour formation. Yet,
senescence cells are also present in non-cancerous states, accumulating exponentially with …
senescence cells are also present in non-cancerous states, accumulating exponentially with …
LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint
N Dimitrova, JR Zamudio, RM Jong, D Soukup… - Molecular cell, 2014 - cell.com
The p53-regulated long noncoding RNA lincRNA-p21 has been proposed to act in trans via
several mechanisms ranging from repressing genes in the p53 transcriptional network to …
several mechanisms ranging from repressing genes in the p53 transcriptional network to …
Mechanisms of human papillomavirus-induced oncogenesis
K Münger, A Baldwin, KM Edwards… - Journal of …, 2004 - journals.asm.org
Papillomaviruses are small nonenveloped viruses with 55-nm-diameter icosahedral capsids
that contain double-stranded DNA genomes of approximately 8,000 bp. They are widely …
that contain double-stranded DNA genomes of approximately 8,000 bp. They are widely …
CDK4: a master regulator of the cell cycle and its role in cancer
The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …
Cyclins and cell cycle checkpoints
▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of
cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase …
cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase …
Notch1 functions as a tumor suppressor in mouse skin
M Nicolas, A Wolfer, K Raj, JA Kummer, P Mill… - Nature …, 2003 - nature.com
Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in
many developmental systems 1, and aberrant Notch signaling is associated with …
many developmental systems 1, and aberrant Notch signaling is associated with …
[HTML][HTML] Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
The role of Notch signaling in growth/differentiation control of mammalian epithelial cells is
still poorly defined. We show that keratinocyte‐specific deletion of the Notch1 gene results in …
still poorly defined. We show that keratinocyte‐specific deletion of the Notch1 gene results in …
Examination of the expanding pathways for the regulation of p21 expression and activity
p21Waf1/Cip1/Sdi1 was originally identified as an inhibitor of cyclin-dependent kinases, a
mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required …
mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required …
Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing …
It has been proposed that the functions of the cyclin-dependent kinase inhibitors
p21Cip1/Waf1 and p27Kip1 are limited to cell cycle control at the G1/S-phase transition and …
p21Cip1/Waf1 and p27Kip1 are limited to cell cycle control at the G1/S-phase transition and …