α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's
Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation …

Considerable evidence supports the release of pathogenic aggregates of the neuronal
protein α-Synuclein (αSyn) into the extracellular space. While this release is proposed to …

α-Synuclein is central in Parkinson's disease pathogenesis. Although initially α-synuclein
was considered a purely intracellular protein, recent data suggest that it can be detected in …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Neurodegeneration is the pathological condition, in which the nervous system or neuron
loses its structure, function, or both, leading to progressive degeneration or the death of …

The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the
defining pathological hallmark of Parkinson's disease (PD). Rare familial PD-associated …

The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are common
neurodegenerative disorders of the aging population, characterized by progressive and …