Optical microscopy is widely used to visualize fine structures. When applied to bioimaging,
its performance is often degraded by sample-induced aberrations. In recent years, adaptive …

Morphogenesis, the process by which tissues develop into functional shapes, requires
coordinated mechanical forces. Most current literature ascribes contractile forces derived …

How tissues acquire complex shapes is a fundamental question in biology and regenerative
medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) …

Morphogenesis is one of the most remarkable examples of biological pattern formation.
Despite substantial progress in the field, we still do not understand the organizational …

During organismal development, organs and systems are built following a genetic blueprint
that produces structures capable of performing specific physiological functions. Interestingly …

Many developmental processes involve the emergence of intercellular fluid-filled lumina.
This process of luminogenesis results in a build up of hydrostatic pressure and signalling …

Animals make organs of precise size, shape, and symmetry but how develo** embryos do
this is largely unknown. Here, we combine quantitative imaging, physical theory, and …

Lumen formation plays an essential role in the morphogenesis of tissues during
development. Here we review the physical principles that play a role in the growth and …

Over the last several decades, studies in humans and animal models have successfully
identified numerous molecules required for hearing and balance. Many of these studies …

Background: The etiology of Meniere's disease (MD) and endolymphatic hydrops believed
to underlie its symptoms remain unknown. One reason may be the exceptional complexity of …