Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …

Schizophrenia is one of the most widespread and complex mental disorders. To
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …

Classic cognitive theory conceptualizes executive functions as involving multiple specific
domains, including initiation, inhibition, working memory, flexibility, planning, and vigilance …

Episodic memory deficits are consistently documented as a core aspect of cognitive
dysfunction in schizophrenia patients, present from the onset of the illness and strongly …

The challenge in understanding cognitive impairment in schizophrenia is that people with
this illness have deficits in an array of domains. Here, we briefly review evidence regarding …

Context Prefrontal cortical dysfunction is frequently reported in schizophrenia. It remains
unclear whether this represents the coincidence of several prefrontal region-and process …

Importance Psychotic disorders (including schizophrenia, schizoaffective disorder, and
psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

All cortical and thalamic levels of sensory processing are subject to powerful top-down
influences, the sha** of lower-level processes by more complex information. New findings …