Background Cutaneous wound healing is a normal physiologic function, observed and
described for centuries by those afflicted with wounds and by those caring for them …

Wound healing involves a series of rapid increases in specific cell populations that prepare
the wound for repair, deposit new matrices and finally, mature the wound. Upon completing …

When tissue loss disrupts normal architecture in higher vertebrate adult animals, the organ
fails to regenerate. Instead, repair proceeds as a fibroproliferative response that develops …

Human atheromas accumulate extracellular matrix proteins such as collagen types I and III.
We tested whether cytokines or growth factors produced by cells found in human …

Reciprocal interactions between epithelium and mesenchyme mediate crucial aspects of
embryonic development and direct the coordinated organogenesis, correct spatial …

The past 2 decades have produced more advances in wound care than have the previous
2000 years as a result of rapid expansion in the knowledge of the healing process at the …

Publisher Summary Interleukin-1 (IL-1) and tumor necrosis factor (TNF) participate in self-
augmentation induction mechanisms. Recombinant human IL-1 and TNF are each capable …

Growth factors have many activities that make them attractive agents for stimulating tissue
repair. Growth factors attract cells into the wound, stimulate their proliferation, and have …

The human response to injury involves the coordinated interplay of a variety of physiologic
processes that result in a healed wound. In a highly reproducible manner, hemostasis is …

Publisher Summary The chapter focuses on the salient issues and most recent advances
concerning IFN-γ's biological function to provide a framework for understanding its role in …