The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for
generating cellular energy and precursors for biosynthetic pathways. Several cancers …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …

Pluripotent stem cells hold great promise in regenerative medicine and developmental
biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle …

Induction of trained immunity (innate immune memory) is mediated by activation of immune
and metabolic pathways that result in epigenetic rewiring of cellular functional programs …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …

Histone modifications, such as the frequently occurring lysine succinylation,, are central to
the regulation of chromatin-based processes. However, the mechanism and functional …

Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

The growing field of tumor metabolism has greatly expanded our knowledge of metabolic
reprogramming in cancer. Apart from their established roles, various metabolic enzymes and …