Plant flavonoids are secondary metabolites containing a benzo-γ-pyrone structure, which
are widely present in plants and have a variety of physiological and pharmacological …

Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

Resveratrol is a polyphenol with numerous applications in food, pharma, and cosmetics.
Lack of precursors and low titer are the main problems hindering industrial scale resveratrol …

Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …

Astaxanthin is a highly value-added keto-carotenoid compound. The astaxanthin 3 S, 3′ S-
isomer is more desirable for food additives, cosmetics, and pharmaceuticals due to health …

Squalene is the precursor for triterpene-based natural products and steroids-based drugs. It
has been widely used as pharmaceutical intermediates and personal care products. The …

CRISPR-Cas9 has been widely adopted as the basic toolkit for precise genome-editing and
engineering in various organisms. Alternative to Cas9, Cas12 or Cpf1 uses a simple crRNA …

The aim of this present research is to enhance the squalene production in Yarrowia
lipolytica using pathway engineering and bioprocess engineering. Firstly, to improve the …

Pathway optimization plays an important role in fine-tuning metabolic pathways. In most
conditions, more than three genes are involved in the biosynthesis pathway of a specific …

Acetyl-CoA is the central metabolic node connecting glycolysis, Krebs cycle and fatty acids
synthase. Plant-derived polyketides, are assembled from acetyl-CoA and malonyl-CoA …