The kidneys are a pair of important organs that excretes endogenous waste and exogenous
biological agents from the body. Numerous transporters are involved in the excretion …

Blockade of human ether-à-go-go related gene (hERG) channel by compounds may lead to
drug-induced QT prolongation, arrhythmia, and Torsades de Pointes (TdP), and therefore …

Drug-transporter interactions could impact renal drug clearance and should ideally be
detected in early stages of drug development to avoid toxicity-related withdrawals in later …

Organic anion and cation transporting proteins (OATs, OATPs, and OCTs), as well as the
Multidrug and Toxin Extrusion (MATE) transporters of the Solute Carrier (SLC) family are …

Simultaneous inhibition of MDM2 and CDK4 may be an effective treatment against
glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene (THN)-oxindole …

Herein, we report an unprecedented implementation of 3-halooxindoles as C–C–O three-
atom components for (3+ 3) cycloaddition with pyridinium 1, 4-zwitterionic thiolates, affording …

Following the reactivity inversion strategy, two different two-step sequences were designed
and successfully applied to the asymmetric synthesis of spiro-bridged and spiro-fused …

SARS-related coronaviruses poses continual threat to humanity by rapidly mutating and
emerging as severe pandemic outbreaks, including the current nCoV-19 pandemic. Hence a …

Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, with an extremely
poor prognosis due to resistance to standard-of-care treatments. Strong evidence suggests …

Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous
compounds and drugs across membranes, thus playing a critical role in disease …