Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

Cytokines are pleotrophic proteins that coordinate the host response to infection as well as
mediate normal, ongoing signaling between cells of nonimmune tissues, including the …

Embryos allocate cells to the three germ layers in a spatially ordered sequence. Human
embryonic stem cells (hESCs) can generate the three germ layers in culture; however …

The earliest aspects of human embryogenesis remain mysterious. To model patterning
events in the human embryo, we used colonies of human embryonic stem cells (hESCs) …

BACKGROUND Classic embryological studies showed that diffusible factors (morphogens)
influence cell fate during dorsal-ventral (DV) axis patterning. Subsequently, mathematical …

Genetic studies have identified the key signalling pathways and developmentally regulated
transcription factors that govern cell lineage allocation and axis patterning in the early …

Large numbers of new neurons are born continuously in the adult subventricular zone
(SVZ). The molecular niche of SVZ stem cells is poorly understood. Here, we show that the …

We have identified a stromal cell–derived inducing activity (SDIA) that promotes neural
differentiation of mouse ES cells. SDIA accumulates on the surface of PA6 stromal cells and …

Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …

Skeletal homeostasis is determined by systemic hormones and local factors. Bone
morphogenetic proteins (BMP) are unique because they induce the differentiation of …