Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases

V Mittelheisser, V Gensbittel, L Bonati, W Li… - Nature …, 2024 - nature.com
Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

[HTML][HTML] Macropinocytosis in different cell types: similarities and differences

XP Lin, JD Mintern, PA Gleeson - Membranes, 2020 - mdpi.com
Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific
internalisation of large amounts of extracellular fluid, solutes and membrane in large …

Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes

Z Alraies, CA Rivera, MG Delgado, D Sanséau… - Nature …, 2024 - nature.com
Immune cells experience large cell shape changes during environmental patrolling because
of the physical constraints that they encounter while migrating through tissues. These cells …

Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity

M de Jesus, AH Settle, D Vorselen, TK Gaetjens… - Science …, 2024 - science.org
Immune cells have intensely physical lifestyles characterized by structural plasticity and
force exertion. To investigate whether specific immune functions require stereotyped …

All roads lead to directional cell migration

A Shellard, R Mayor - Trends in cell biology, 2020 - cell.com
Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …

Collective behaviors of active matter learning from natural taxes across scales

F Ji, Y Wu, M Pumera, L Zhang - Advanced Materials, 2023 - Wiley Online Library
Taxis orientation is common in microorganisms, and it provides feasible strategies to
operate active colloids as small‐scale robots. Collective taxes involve numerous units that …

Principles of leukocyte migration strategies

P Kameritsch, J Renkawitz - Trends in cell biology, 2020 - cell.com
Migration of leukocytes is essential for the induction, maintenance, and regulation of
immune responses. On their trafficking routes, leukocytes encounter microenvironments of …

[HTML][HTML] Macropinocytosis: Biology and mechanisms

RR Kay - Cells & development, 2021 - Elsevier
Macropinocytosis is a form of endocytosis performed by ruffles and cups of the plasma
membrane. These close to entrap droplets of medium into micron-sized vesicles, which are …

Molecular mechanisms of dendritic cell migration in immunity and cancer

CM de Winde, C Munday, SE Acton - Medical microbiology and …, 2020 - Springer
Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells that act to
bridge innate and adaptive immunity. DCs are critical in mounting effective immune …

Spoiled for choice: diverse endocytic pathways function at the cell surface

JJ Thottacherry, M Sathe… - Annual review of cell …, 2019 - annualreviews.org
Endocytosis has long been identified as a key cellular process involved in bringing in
nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in …