PVT1, a long non-coding RNA has been implicated in a variety of human cancers. Recent
advancements have led to increasing discovery of the critical roles of PVT1 in cancer …

Over 60 bromodomains belonging to proteins with very different functions have been
identified in humans. Several of them interact with acetylated lysine residues, leading to the …

Purpose: MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and
extraterminal (BET) bromodomain inhibition has recently been shown to suppress MYC …

Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …

The brain is a common site of metastatic disease in patients with breast cancer, which has
few therapeutic options and dismal outcomes. The purpose of our study was to identify …

Cancer genomes maintain a complex array of somatic alterations required for maintenance
and progression of the disease, posing a challenge to identify driver genes among this …

Systematic efforts to sequence the cancer genome have identified large numbers of
mutations and copy number alterations in human cancers. However, elucidating the …

The DNA-encoded library (DEL) discovery platform has emerged as a powerful technology
for hit identification in recent years. It has become one of the major parallel workstreams for …

ATAD2 (ANCCA) is an epigenetic regulator and transcriptional cofactor, whose
overexpression has been linked to the progress of various cancer types. Here, we report a …

Simple Summary This review provides an in depth analysis of the role of bromodomain-
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …