Neuroinflammation and status epilepticus: a narrative review unraveling a complex interplay

T Foiadelli, A Santangelo, G Costagliola… - Frontiers in …, 2023 - frontiersin.org
Status epilepticus (SE) is a medical emergency resulting from the failure of the mechanisms
involved in seizure termination or from the initiation of pathways involved in abnormally …

Urinary biomarkers for amyotrophic lateral sclerosis: candidates, opportunities and considerations

ML Rogers, DW Schultz, V Karnaros… - Brain …, 2023 - academic.oup.com
Amyotrophic lateral sclerosis is a relentless neurodegenerative disease that is mostly fatal
within 3–5 years and is diagnosed on evidence of progressive upper and lower motor …

Metabolomic changes in adults with status epilepticus: a human case–control study

A Hanin, C Chollet, S Demeret, L Di Meglio… - …, 2024 - Wiley Online Library
Objective Status epilepticus (SE) is a life‐threatening prolonged epileptic seizure that
affects~ 40 per 100 000 people yearly worldwide. The persistence of seizures may lead to …

Effect of gut microbiota-mediated tryptophan metabolism on inflammaging in frailty and sarcopenia

YS Xu, T Mao, YJ Wang, XS Qi, WJ Zhao… - The Journals of …, 2024 - academic.oup.com
Frailty syndrome refers to the nonspecific state of increased body vulnerability and
decreased antistress and recovery abilities after stress during aging. Sarcopenia is the …

CNS disease associated with enhanced type I interferon signalling

YJ Crow - The Lancet Neurology, 2024 - thelancet.com
The ability to mount an interferon-mediated innate immune response is essential in
protection against neurotropic viruses, but antiviral type I interferons also have neurotoxic …

[HTML][HTML] Neopterin mediates sleep deprivation-induced microglial activation resulting in neuronal damage by affecting YY1/HDAC1/TOP1/IL-6 signaling

X Li, Z Kong, K Cai, F Qi, S Zhu - Journal of Advanced Research, 2024 - Elsevier
Introduction Sleep deprivation (SD) is a common disorder in modern society. Hippocampus
is an important region of the brain for learning, memory, and emotions. Dysfunction of …

Implications of Kynurenine Pathway Metabolism for the Immune System, Hypothalamic–Pituitary–Adrenal Axis, and Neurotransmission in Alcohol Use Disorder

B Osuch, T Misztal, K Pałatyńska… - International Journal of …, 2024 - mdpi.com
In recent years, there has been a marked increase in interest in the role of the kynurenine
pathway (KP) in mechanisms associated with addictive behavior. Numerous reports …

Structural characteristics and potential antidepressant mechanism of a water-insoluble β-1, 3-glucan from an edible fungus Wolfiporia cocos

XY Luo, M Yu, HJ Li, XY Kong, ZM Zou, XC Ye - Carbohydrate Polymers, 2025 - Elsevier
Abstract A water-insoluble β-1, 3-glucan (Wβ) with a molecular weight of 8.12× 10 4 Da was
extracted from an edible fungus Wolfiporia cocos. Its backbone was composed of 1, 3-β …

Abnormal kynurenine-pathway metabolites in gout: Biomarkers exploration based on orthogonal partial least squares-discriminant analysis

Z Liu, L **, Z Ma, X Nizhamuding, J Zeng, T Zhang… - Clinica Chimica …, 2023 - Elsevier
Background This study aims to investigate serological characteristics of kynurenine pathway
(KP) metabolites in healthy controls (HC) and gout patients and explore possible differential …

Increased Tryptophan Catabolism Provides Predictive Value to Chronic Heart Failure Patients with Low-Grade Inflammation

H Wang, J Wu, H Wei, Y Zhang, Y Wang, DW Wang - Inflammation, 2024 - Springer
Kynurenine to tryptophan ratio (KTR), which serves as an indicator for evaluating
indoleamine-2, 3-dioxygenase activity and inflammation, has been reported to be linked with …