Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer–A comprehensive review from chemotherapy to immunotherapy
Breast cancer is the most frequently occurring cancer in women. Chemotherapy in
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …
Common genetic variation influencing human white matter microstructure
INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
A large multiethnic genome-wide association study of adult body mass index identifies novel loci
TJ Hoffmann, H Choquet, J Yin, Y Banda, MN Kvale… - Genetics, 2018 - academic.oup.com
Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …
PI3K–AKT-Targeting breast cancer treatments: Natural products and synthetic compounds
Y Yuan, H Long, Z Zhou, Y Fu, B Jiang - Biomolecules, 2023 - mdpi.com
Breast cancer is the most commonly diagnosed cancer in women. The high incidence of
breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K …
breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K …
Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
Neuronal migration is a fundamental process that governs embryonic brain development. As
such, mutations that affect essential neuronal migration processes lead to severe brain …
such, mutations that affect essential neuronal migration processes lead to severe brain …
Phosphoinositides: regulators of nervous system function in health and disease
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …
emerged as regulators of key sub-cellular processes such as membrane transport …
Malformations of cerebral cortex development: molecules and mechanisms
Malformations of cortical development encompass heterogeneous groups of structural brain
anomalies associated with complex neurodevelopmental disorders and diverse genetic and …
anomalies associated with complex neurodevelopmental disorders and diverse genetic and …
Megalencephaly syndromes associated with mutations of core components of the PI3K‐AKT–MTOR pathway: PIK3CA, PIK3R2, AKT3, and MTOR
Megalencephaly (MEG) is a developmental abnormality of brain growth characterized by
early onset, often progressive, brain overgrowth. Focal forms of megalencephaly associated …
early onset, often progressive, brain overgrowth. Focal forms of megalencephaly associated …
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
L Truebestein, H Hornegger… - Proceedings of the …, 2021 - National Acad Sciences
The protein kinase Akt is one of the primary effectors of growth factor signaling in the cell. Akt
responds specifically to the lipid second messengers phosphatidylinositol-3, 4, 5 …
responds specifically to the lipid second messengers phosphatidylinositol-3, 4, 5 …