Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction
between host‐specific genetic background and multiple risk factors. Globally, CCA …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Haemochromatosis is characterised by elevated transferrin saturation (TSAT) and
progressive iron loading that mainly affects the liver. Early diagnosis and treatment by …

Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled
intestinal iron absorption may lead to progressive iron overload (IO) responsible for …

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for
Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant …

Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …

Hereditary hemochromatosis (HH) is one of the most common genetic disorders among
persons of northern European descent. There have been recent advances in the diagnosis …

Phasing involves distinguishing the two parentally inherited copies of each chromosome
into haplotypes. Here, we introduce SHAPEIT5, a new phasing method that quickly and …

Iron is an essential element in biology, required for numerous cellular processes. Either too
much or too little iron can be detrimental, and organisms have developed mechanisms for …

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