Although diet has long been known to contribute to the pathogenesis of cardiovascular
disease (CVD), research over the past decade has revealed an unexpected interplay …

The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which
include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin …

Aims Understanding the novel signalling pathways involved in the pathogenesis of
hypertension is vital for the development of effective therapeutic strategies. Recent evidence …

Mutations in the genes encoding Leucine Rich Repeat (LRR) containing proteins are
associated with over sixty human diseases; these include high myopia, mitochondrial …

Aim: Angiotensin Ⅱ (Ang Ⅱ) produces reactive oxygen species (ROS), thus contributing to
the development of cardiac hypertrophy and subsequent heart failure, and stimulates the …

Abstract Toll-Like receptors (TLRs) are the primary receptors of innate immunity.
Considerable evidences have shown that innate immune defence interaction with pro …

Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-
associated molecular patterns, are critical for the normal function of the innate immune …

Despite intensive research, the exact cause of hypertension remains unknown. Low-grade
inflammation has been proposed to play a key role in the pathogenesis of hypertension …

In spite of the high rate of morbidity and mortality heart failure (HF) is common, and none of
the medications are now entirely available for HF treatment. In addition to many …

The aim of this study was to compare the expression of serum microRNAs (miRNAs) in
individuals with spinal cord injury (SCI)(athletes [SCI-A] and sedentary [SCI-S]) and able …