Compared to most mammals, human pregnancy is unusual in that it involves chromosomally
diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate …

Advances in next generation sequencing have allowed for rapid and economical germline
and tumor genomic profiling. Targeted therapies based on molecular tumor profiling are now …

The limited efficacy of immune checkpoint inhibitor treatment in triple-negative breast cancer
(TNBC) patients is attributed to sparse or unresponsive tumor-infiltrating lymphocytes, but …

Skull-base chordoma is a rare, aggressive bone cancer with a high recurrence rate. Despite
advances in genomic studies, its molecular characteristics and effective therapies remain …

Copy number alterations (CNAs) are pivotal genetic events in triple-negative breast cancer
(TNBC). Here, our integrated copy number and transcriptome analysis of 302 TNBC patients …

Chromosomal instability is a major challenge to patient stratification and targeted drug
development for high-grade serous ovarian carcinoma (HGSOC). Here we show that …

Although metastatic disease is the leading cause of cancer-related deaths, its tumor
microenvironment remains poorly characterized due to technical and biospecimen …

Oncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression,
causes genomic instability and has been linked to tumorigenesis. To survive high levels of …

Subclonal copy number alterations are a prevalent feature in tumors with high chromosomal
instability and result in heterogeneous cancer cell populations with distinct phenotypes …

Integrin β1 (ITGB1), which acts as an extracellular matrix (ECM) receptor, has gained
increasing attention as a therapeutic target for the treatment of hepatocellular carcinoma …