The blood–retina barrier in health and disease

F O'Leary, M Campbell - The FEBS Journal, 2023 - Wiley Online Library
The blood–retina barrier (BRB) is the term used to define the properties of the retinal
capillaries and the retinal pigment epithelium (RPE), which separate the systemic circulation …

The impact of oxidative stress on blood-retinal barrier physiology in age-related macular degeneration

A Tisi, M Feligioni, M Passacantando, M Ciancaglini… - Cells, 2021 - mdpi.com
The blood retinal barrier (BRB) is a fundamental eye component, whose function is to select
the flow of molecules from the blood to the retina and vice-versa, and its integrity allows the …

The structure and function of the human choroid

W Zhang, A Kaser-Eichberger, W Fan, C Platzl… - Annals of Anatomy …, 2024 - Elsevier
In this manuscript, the structure of the human choroid is reviewed with emphasis of the
macro-and microscopic anatomy including Bruch's membrane, choriocapillaris, Sattler's and …

Proline metabolism and transport in retinal health and disease

J Du, S Zhu, RR Lim, JR Chao - Amino acids, 2021 - Springer
The retina is one of the most energy-demanding tissues in the human body. Photoreceptors
in the outer retina rely on nutrient support from the neighboring retinal pigment epithelium …

Retinal cell transplantation, biomaterials, and in vitro models for develo** next-generation therapies of age-related macular degeneration

LJ Rizzolo, IO Nasonkin… - Stem cells translational …, 2022 - academic.oup.com
Retinal pigment epithelium (RPE) cells grown on a scaffold, an RPE patch, have potential to
ameliorate visual impairment in a limited number of retinal degenerative conditions. This …

Understanding the impact of polyunsaturated fatty acids on age-related macular degeneration: a review

M Brito, C Sorbier, N Mignet, V Boudy… - International Journal of …, 2024 - mdpi.com
Age-related Macular Degeneration (AMD) is a multifactorial ocular pathology that destroys
the photoreceptors of the macula. Two forms are distinguished, dry and wet AMD, with …

[HTML][HTML] Neutrophils and neutrophil extracellular trap components: Emerging biomarkers and therapeutic targets for age-related eye diseases

I Martínez-Alberquilla, X Gasull, P Pérez-Luna… - Ageing Research …, 2022 - Elsevier
Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration,
and diabetic retinopathy, represent a major global health issue based on their increasing …

Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration

K Gill, HS Yoo, H Chakravarthy, DJ Granville… - Frontiers in …, 2024 - frontiersin.org
Age-related macular degeneration (AMD), a prevalent and progressive degenerative
disease of the macula, is the leading cause of blindness in elderly individuals in developed …

Quantitative Proteomics of Human Retinal Pigment Epithelium Reveals Key Regulators for the Pathogenesis of Age-Related Macular Degeneration

S Shen, RJ Kapphahn, M Zhang, S Qian… - International journal of …, 2023 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of blindness in elderly
people, with limited treatment options available for most patients. AMD involves the death of …

Conditional loss of Ube3d in the retinal pigment epithelium accelerates age‐associated alterations in the retina of mice

T Tao, N Xu, J Li, M Zhao, X Li… - The Journal of …, 2023 - Wiley Online Library
Several studies have suggested a correlation between the ubiquitin‐proteasome system
(UPS) and age‐related macular degeneration (AMD), with its phenotypic severity ranging …