Microrobots for biomedicine: unsolved challenges and opportunities for translation

JG Lee, RR Raj, NB Day, CW Shields IV - ACS nano, 2023 - ACS Publications
Microrobots are being explored for biomedical applications, such as drug delivery, biological
cargo transport, and minimally invasive surgery. However, current efforts largely focus on …

Biocompatible polymer-based micro/nanorobots for theranostic translational applications

H Kim, K Jo, H Choi, SK Hahn - Journal of Controlled Release, 2024 - Elsevier
Abstract Recently, micro/nanorobots (MNRs) with self-propulsion have emerged as a
promising smart platform for diagnostic, therapeutic and theranostic applications. Especially …

Polyoxometalate‐Nanozyme‐Integrated Nanomotors (POMotors) for Self‐Propulsion‐Promoted Synergistic Photothermal‐Catalytic Tumor Therapy

M Tang, J Ni, Z Yue, T Sun, C Chen, X Ma… - Angewandte …, 2024 - Wiley Online Library
Enzyme‐powered nanomotors have demonstrated promising potential in biomedical
applications, especially for catalytic tumor therapy, owing to their ability of self‐propulsion …

Collective buoyancy-driven dynamics in swarming enzymatic nanomotors

S Chen, X Peetroons, AC Bakenecker… - Nature …, 2024 - nature.com
Enzymatic nanomotors harvest kinetic energy through the catalysis of chemical fuels. When
a drop containing nanomotors is placed in a fuel-rich environment, they assemble into …

Strategic assessment of boron-enriched carbon dots/naproxen: diagnostic, toxicity, and in vivo therapeutic evaluation

A Wibrianto, FSD Putri, UK Nisa… - Molecular …, 2024 - ACS Publications
Cancer is a significant global public health concern, ranking as the leading cause of
mortality worldwide. This study thoroughly explores boron-doped carbon dots (B-CDs) …

Targeted Drug Delivery: From Chemistry to Robotics at Small Scales

M Kim, JD Nicholas, J Puigmartí-Luis… - Annual Review of …, 2024 - annualreviews.org
The limited bioavailability, susceptibility to degradation, and adverse side effects of novel
drugs often hinder their effective administration. Nanoparticles, with customizable properties …

Enzymatic micro/nanomotors in biomedicine: from single motors to swarms

S Chen, C Prado-Morales… - Journal of Materials …, 2024 - pubs.rsc.org
Micro/nanomotors (MNMs) have evolved from single self-propelled entities to versatile
systems capable of performing one or multiple biomedical tasks. When single MNMs self …

Hyaluronic acid-targeted dual-bubble/photothermal-driven nanomissile for enhanced “four-in-one” anti-tumor strategy

F Ouyang, Y Liu, L Zhang, Q Shuai - International Journal of Biological …, 2024 - Elsevier
The dense extracellular matrix and high interstitial pressure affect the diffusion of nanodrug
in tumor tissue, resulting in a small range of action of the active components in nanodrug …

Swarms of Enzyme‐Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media

N Ruiz‐González, D Esporrín‐Ubieto, AC Hortelao… - Small, 2024 - Wiley Online Library
Over the past decades, the development of nanoparticles (NPs) to increase the efficiency of
clinical treatments has been subject of intense research. Yet, most NPs have been reported …

Catalase-Powered Nanobots for Overcoming the Mucus Barrier

M Serra-Casablancas, V Di Carlo, D Esporrín-Ubieto… - ACS …, 2024 - ACS Publications
Biological barriers present a significant obstacle to treatment, especially when drugs are
administered locally to increase their concentrations at the target site while minimizing …