The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle
that is assembled and turned over at designated sites. The cell wall also functions as a …

A decisive step in the biosynthesis of many proteins is their partial or complete translocation
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …

The unifying feature of all proteins that are transported out of the cytoplasm of gram-negative
bacteria by the general secretory pathway (GSP) is the presence of a long stretch of …

Bacilli secrete numerous proteins into the environment. Many of the secretory proteins, their
export signals, and their processing steps during secretion have been characterized in …

Most major systems that transport proteins across a membrane share the following features:
an amino-terminal transient signal sequence on the transported protein, a targeting system …

We have previously reconstituted the soluble phase of precursor protein translocation in
vitro using purified proteins (the precursor proOmpA, the chaperone SecB, and the ATPase …

The export of many E. coli proteins such as pmOmpA requires the cytosolic chaperone SecB
and the membrane-bound preprotein translocase. Translocase is a multisubunit enzyme …

Subcellular compartments have unique protein compositions, yet protein synthesis only
occurs in the cytosol and in mitochondria and chloroplasts. How do proteins get where they …

The cell wall peptidoglycan of Gram-positive bacteria functions as a surface organelle for the
transport and assembly of proteins that interact with the environment, in particular, the …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …