Cytokines produced by immune cells contribute to the development and perpetuation of
inflammatory bowel disease (IBD), namely Crohn's disease and ulcerative colitis, by …

Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …

Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the
disruption of their integrity contributes to local and gut-distal pathologies. Yet, the …

Signature Cytokines and Immune-Mediated Inflammatory Diseases The ability to block
specific cytokine pathways has revealed pathophysiological differences among autoimmune …

IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Pathophysiology of Inflammatory Bowel Diseases Research on IBDs has identified disrupted
immune responses in the gastrointestinal mucosa and putative disruptions in the gut …