BACKGROUND The metabolome of any given biological system contains a diverse range of
low molecular weight molecules (metabolites), whose abundances can be affected by the …

The circadian clock and feeding rhythms are both important regulators of rhythmic gene
expression in the liver. To further dissect the respective contributions of feeding and the …

Glucocorticoids, vertebrate steroid hormones produced by cells of the adrenal cortex or
interrenal tissue, function dynamically to maintain homeostasis under constantly changing …

The development and regulation of malignant self-renewal remain unresolved issues. Here,
we provide biochemical, genetic, and functional evidence that dynamics in ribosomal RNA …

Plant and inflorescence architecture determine the yield potential of crops. Breeders have
harnessed natural diversity for inflorescence architecture to improve yields, and induced …

The malate shuttle is traditionally understood to maintain NAD+/NADH balance between the
cytosol and mitochondria. Whether the malate shuttle has additional functions is unclear …

Hypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore
glucose homeostasis, a response that is impaired in patients with diabetes and its long-term …

The causes of the physiological effects of microplastic pollution, potentially harming reef-
building corals, are unclear. Reasons might include increased energy demands for handling …

The pdx1−/− zebrafish mutant was recently established as a novel animal model of diabetic
retinopathy. In this study, we investigate whether knockout of pdx1 also leads to diabetic …

The increased formation of methylglyoxal (MG) under hyperglycemia is associated with the
development of microvascular complications in patients with diabetes mellitus; however, the …