Sex characteristics exhibit significant disparities in various human diseases, including
prevalent cardiovascular diseases, cancers, metabolic disorders, autoimmune diseases …

Brown adipose tissue (BAT) plays an important role in energy homeostasis by generating
heat from chemical energy via uncoupled oxidative phosphorylation. Besides its high …

Background Epigenetic modifiers, such as methyltransferases, play crucial roles in the
regulation of many biological processes, including development, cancer and multiple …

Abstract PERM1 (PGC-1/ERR-induced regulator in muscle 1) is a muscle-specific protein
induced by PGC-1 and ERRs. Previous studies have shown that PERM1 promotes …

Aims PERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We
previously demonstrated that PERM1 is downregulated in the failing heart and that PERM1 …

Background The histone-lysine N-methyltransferase SMYD1, which is specific to striated
muscle, plays a crucial role in regulating early heart development. Its deficiency has been …

The heart undergoes a dynamic maturation process following birth, in response to a wide
range of stimuli, including both physiological and pathological cues. This process entails …

Smyd1, a member of the Smyd lysine methyltransferase family, plays an important role in
myofibrillogenesis of skeletal and cardiac muscles. Loss of Smyd1b (a Smyd1 ortholog) …

Normal contractile function of the heart depends on a constant and reliable production of
ATP by cardiomyocytes. Dysregulation of cardiac energy metabolism can result in immature …

SET and MYND domain-containing protein 1 (Smyd1) is a striated muscle-specific histone
methyltransferase. Our previous work demonstrated that deletion of Smyd1 in either …