Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) III protein uniquely found
in astrocytes in the central nervous system (CNS), non-myelinating Schwann cells in the …

As the major cellular component of the innate immune system in the central nervous system
(CNS) and the first line of defense whenever injury or disease occurs, microglia play a …

Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

Traumatic brain injury leads to cellular damage which in turn results in the rapid release of
damage-associated molecular patterns (DAMPs) that prompt resident cells to release …

Neuronal inflammation is the characteristic pathologic change of acute neurologic
impairment and chronic traumatic encephalopathy after traumatic brain injury (TBI) …

Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

Traumatic brain injury (TBI) is a serious public health problem accounting for 1.4 million
emergency room visits by US citizens each year. Although TBI has been traditionally …