Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …

The hepatitis C virus (HCV) is a small enveloped RNA virus belonging to the family
flaviviridae and genus hepacivirus. The HCV RNA genome is 9,600 nucleotides in length …

Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …

The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

RNA nanoparticles have applications in the treatment of cancers and viral infection;
however, the instability of RNA nanoparticles has hindered their applications for therapeutic …

Intracellular infectious hepatitis C virus (HCV) particles display a distinctly higher buoyant
density than do secreted virus particles, suggesting that the characteristic low density of …

Initiation of protein synthesis in eukaryotes requires recruitment of the 40 S ribosomal
subunit to the messenger RNA (mRNA). In most cases, this depends on recognition of a …

Many viruses and certain cellular mRNAs initiate protein synthesis from a highly structured
RNA sequence in the 5′ untranslated region, called the internal ribosome entry site (IRES) …

ABSTRACT miR-122 is a liver-specific microRNA that positively regulates hepatitis C virus
(HCV) RNA abundance and is essential for production of infectious HCV. Using a genetic …

Hepatitis C virus (HCV) infection is a major health problem in Egypt, where the
seroprevalence is 10–20-fold higher than that in the United States. To characterize the HCV …