Intelligent image-based deformation-assisted cell sorting with molecular specificity

AA Nawaz, M Urbanska, M Herbig, M Nötzel, M Kräter… - Nature …, 2020 - nature.com
Although label-free cell sorting is desirable for providing pristine cells for further analysis or
use, current approaches lack molecular specificity and speed. Here, we combine real-time …

Building block properties govern granular hydrogel mechanics through contact deformations

DB Emiroglu, A Bekcic, D Dranseike, X Zhang… - Science …, 2022 - science.org
Granular hydrogels have been increasingly exploited in biomedical applications, including
wound healing and cardiac repair. Despite their utility, design guidelines for engineering …

Cell spheroid fusion: beyond liquid drops model

NV Kosheleva, YM Efremov, BS Shavkuta, IM Zurina… - Scientific reports, 2020 - nature.com
Biological self-assembly is crucial in the processes of development, tissue regeneration, and
maturation of bioprinted tissue-engineered constructions. The cell aggregates—spheroids …

Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease

J Baumann, L Sachs, O Otto, I Schoen, P Nestler… - Science …, 2022 - science.org
MYH9-related disease patients with mutations in the contractile protein nonmuscle myosin
heavy chain IIA display, among others, macrothrombocytopenia and a mild-to-moderate …

Mechanical properties of membranes composed of gel-phase or fluid-phase phospholipids probed on liposomes by atomic force spectroscopy

O Et-Thakafy, N Delorme, C Gaillard, C Mériadec… - Langmuir, 2017 - ACS Publications
In many liposome applications, the nanomechanical properties of the membrane envelope
are essential to ensure, eg, physical stability, protection, or penetration into tissues. Of all …

Standardized microgel beads as elastic cell mechanical probes

S Girardo, N Traeber, K Wagner, G Cojoc… - Journal of Materials …, 2018 - pubs.rsc.org
Cell mechanical measurements are gaining increasing interest in biological and biomedical
studies. However, there are no standardized calibration particles available that permit the …

Oncogenic signaling alters cell shape and mechanics to facilitate cell division under confinement

HK Matthews, S Ganguli, K Plak, AV Taubenberger… - Developmental Cell, 2020 - cell.com
To divide in a tissue, both normal and cancer cells become spherical and mechanically
stiffen as they enter mitosis. We investigated the effect of oncogene activation on this …

Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development

N Traeber, K Uhlmann, S Girardo, G Kesavan… - Scientific reports, 2019 - nature.com
Mechanical stress exerted and experienced by cells during tissue morphogenesis and
organ formation plays an important role in embryonic development. While techniques to …

Mechanical characterization of soft microparticles prepared by droplet microfluidics

E Kim, H Lee - Journal of Polymer Science, 2022 - Wiley Online Library
Droplet microfluidics is one of the most promising approaches that allows preparation of
microparticles with tailored structure and composition. Various functional microparticles …

Stiffness of HIV‐1 Mimicking Polymer Nanoparticles Modulates Ganglioside‐Mediated Cellular Uptake and Trafficking

B Eshaghi, N Alsharif, X An, H Akiyama… - Advanced …, 2020 - Wiley Online Library
The monosialodihexosylganglioside, GM3, and its binding to CD169 (Siglec‐1) have been
indicated as key factors in the glycoprotein‐independent sequestration of the human …