The role of inflammasomes in human diseases and their potential as therapeutic targets
J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …
signals and triggering the innate immune response. Each inflammasome complex has three …
[HTML][HTML] Advances in the roles of ATF4 in osteoporosis
Y **ao, X **e, Z Chen, G Yin, W Kong, J Zhou - Biomedicine & …, 2023 - Elsevier
Osteoporosis (OP) is characterized by reduced bone mass, decreased strength, and
enhanced bone fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in …
enhanced bone fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in …
Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease
Alzheimer's disease (AD) is the most prevalent cause of dementia and is characterized by
low levels of acetyl and butyrylcholine, increased oxidative stress, inflammation …
low levels of acetyl and butyrylcholine, increased oxidative stress, inflammation …
Gingerenone A Attenuates Ulcerative Colitis via Targeting IL‐17RA to Inhibit Inflammation and Restore Intestinal Barrier Function
J Liang, W Dai, C Liu, Y Wen, C Chen, Y Xu… - Advanced …, 2024 - Wiley Online Library
Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available
drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently …
drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently …
Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice
H Xu, W Li, S Hong, J Shao, J Chen… - Acta Pharmacologica …, 2023 - nature.com
Aberrant activation of NLRP3 inflammasome causes the progression of various inflammation-
related diseases, but the small-molecule inhibitors of NLRP3 are not currently available for …
related diseases, but the small-molecule inhibitors of NLRP3 are not currently available for …
Target discovery of bioactive natural products with Native-compound-Coupled CNBr-activated Sepharose 4B Beads (NCCB): applications, mechanisms and outlooks
Y Zhang, J Zhang, M Li, Y Qiao, W Wang, L Ma… - Bioorganic & Medicinal …, 2023 - Elsevier
Natural products (NPs) represent a treasure trove for drug discovery and development due
to their chemical structural diversity and a broad spectrum of biological activities. Uncovering …
to their chemical structural diversity and a broad spectrum of biological activities. Uncovering …
Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome
S Xu, Y Zhang, Z Zheng, J Sun, Y Wei, G Ding - Human Cell, 2024 - Springer
The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing
3 (NLRP3) inflammasome is a cytosolic multi-subunit protein complex, and recent studies …
3 (NLRP3) inflammasome is a cytosolic multi-subunit protein complex, and recent studies …
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB …
X Shen, H Chen, H Zhang, L Luo, T Wen, L Liu… - International …, 2023 - Elsevier
Isolinderalactone is the main sesquiterpene lactone isolated from Lindera aggregata, a
traditional Chinese medicine widely used to treat pain and inflammation. Although …
traditional Chinese medicine widely used to treat pain and inflammation. Although …
Novel MAGL inhibitors alleviate LPS-induced acute kidney injury by inhibiting NLRP3 inflammatory vesicles, modulating intestinal flora, repairing the intestinal barrier …
H **ang, Y Wang, L Yang, M Liu, C Sun, Y Gu, J Yao - Molecules, 2023 - mdpi.com
Acute kidney injury (AKI) is a complication of a wide range of serious illnesses for which
there is still no better therapeutic agent. We demonstrated that M-18C has a favorable …
there is still no better therapeutic agent. We demonstrated that M-18C has a favorable …
Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway
Z Niu, X Li, X Yang, Z Sun - Inflammopharmacology, 2024 - Springer
Abstract Background Dextran Sulfate Sodium (DSS) induces ulcerative colitis (UC), a type of
inflammatory bowel disease (IBD) that leads to inflammation, swelling, and ulcers in the …
inflammatory bowel disease (IBD) that leads to inflammation, swelling, and ulcers in the …