The increasing prevalence of infections caused by multidrug-resistant bacteria is a global
health problem that has been exacerbated by the dearth of novel classes of antibiotics …

In the biofilm form, bacteria are more resistant to various antimicrobial treatments. Bacteria in
a biofilm can also survive harsh conditions and withstand the host's immune system …

Biofilm formation significantly contributes to microbial survival in hostile environments and it
is currently considered a key virulence factor for pathogens responsible for serious chronic …

β-Lactam antibiotics are one of the most important antibiotic classes but are plagued by
problems of resistance, and the development of new β-lactam antibiotics through side-chain …

Methicillin-resistant Staphylococcus aureus (MRSA), as a classic reason for genuine skin
and flimsy tissues diseases, is a worldwide general wellbeing risk and has already …

There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …

Highlights•Biofilms are inherently resistant to antibiotics and are a major health
threat.•Quorum sensing antagonists inhibit biofilm formation.•Inhibition of two-component …

Staphylococci are Gram-positive bacteria that are ubiquitous in the environment and able to
form biofilms on a range of surfaces. They have been associated with a range of human …

The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …

Staphylococci, in particular Staphylococcus aureus and Staphylococcus epidermidis, are a
leading cause of healthcareassociated infections. Patients who have a medical device …