Cellular and molecular waypoints along the path of T cell exhaustion
Thirty years of foundational research investigating molecular and cellular mechanisms
promoting T cell exhaustion are now enabling rational design of T cell–based therapies for …
promoting T cell exhaustion are now enabling rational design of T cell–based therapies for …
Inborn errors of human IKAROS: LOF and GOF variants associated with primary immunodeficiency
HS Kuehn, B Boast… - Clinical and Experimental …, 2023 - academic.oup.com
IKAROS/IKZF1 plays a pivotal role in lymphocyte differentiation and development. Germline
mutations in IKZF1, which have been shown to be associated with primary …
mutations in IKZF1, which have been shown to be associated with primary …
Human inborn errors of immunity: 2022 update on the classification from the international union of immunological societies expert committee
SG Tangye, W Al-Herz, A Bousfiha… - Journal of clinical …, 2022 - Springer
We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …
International Union of Immunological Societies Expert Committee. This report documents the …
[HTML][HTML] Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy
S Bonazzi, E d'Hennezel, REJ Beckwith, L Xu… - Cell Chemical …, 2023 - cell.com
Malignant tumors can evade destruction by the immune system by attracting immune-
suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a …
suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a …
Human transcription factor protein interaction networks
H Göös, M Kinnunen, K Salokas, Z Tan, X Liu… - Nature …, 2022 - nature.com
Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …
Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses
Immune aging combines cellular defects in adaptive immunity with the activation of
pathways causing a low-inflammatory state. Here we examined the influence of age on the …
pathways causing a low-inflammatory state. Here we examined the influence of age on the …
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
P Bastard, A Gervais, M Taniguchi, L Saare… - Journal of Experimental …, 2024 - rupress.org
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …
A sensitive assay for measuring whole-blood responses to type I IFNs
Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α,-β,
and/or-ω can underlie severe viral illnesses. We report a simple assay for the detection of …
and/or-ω can underlie severe viral illnesses. We report a simple assay for the detection of …
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023
P Bastard, A Gervais, T Le Voyer… - Immunological …, 2024 - Wiley Online Library
Human autoantibodies (auto‐Abs) neutralizing type I IFNs were first discovered in a woman
with disseminated shingles and were described by Ion Gresser from 1981 to 1984. They …
with disseminated shingles and were described by Ion Gresser from 1981 to 1984. They …
The link between rheumatic disorders and inborn errors of immunity
G Sogkas, T Witte - EBioMedicine, 2023 - thelancet.com
Inborn errors of immunity (IEIs) are immunological disorders characterized by variable
susceptibility to infections, immune dysregulation and/or malignancies, as a consequence of …
susceptibility to infections, immune dysregulation and/or malignancies, as a consequence of …