Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular docking studies of new imidazolyl hydrazone derivatives
A new series of imidazolyl hydrazone derivatives IA (1-12) were prepared from a
condensation reaction between indoline-2, 3-dione (isatin) and 2 …
condensation reaction between indoline-2, 3-dione (isatin) and 2 …
Design, synthesis, characterization, molecular docking studies and anticancer activity evaluation of novel hydrazinecarbothioamide, 1, 2, 4-triazole-3-thione, 4 …
ED Dincel, Ç Akdağ, T Kayra, ED Coşar… - Journal of Molecular …, 2022 - Elsevier
A series of novel hydrazinecarbothioamide, 1, 2, 4-triazole-3-thione, 4-thiazolidinone and 1,
3, 4-oxadiazole derivatives were synthesized and evaluated for their cytotoxic activity …
3, 4-oxadiazole derivatives were synthesized and evaluated for their cytotoxic activity …
Synthesis, molecular docking study of thiazole derivatives and exploring their dual inhibitor potentials against α-amylase and α-glucosidase
Diabetes mellitus is one of the most chronic metabolic diseases. The current study
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
Design, synthesis, molecular docking, dynamics simulations and antiviral activities of quinoline derivatives
The designed and synthesized quinoline derivatives were screened for their anti-RSV, anti-
YFV and broad spectrum anti-viral activity. Initially, physicochemical and drug-like properties …
YFV and broad spectrum anti-viral activity. Initially, physicochemical and drug-like properties …
Design, synthesis, biological evaluation, molecular docking, and dynamic simulation study of novel imidazo [2, 1-b] thiazole derivatives as potent antioxidant agents
A series of novel hydrazinecarbothioamide and 1, 2, 4-triazole-3-thione derivatives of
imidazo [2, 1-b] thiazole were synthesized and evaluated for their antioxidant activity. The …
imidazo [2, 1-b] thiazole were synthesized and evaluated for their antioxidant activity. The …
Evaluation of the Antihyperglycemic efficacy of the roots of Ferula orientalis L.: An in vitro to in vivo assessment
Decoctions of Ferula orientalis L.(Apiaceae), have been traditionally used to lower blood
glucose levels (BGLs). After in vitro enzyme inhibition tests on the dichloromethane extracts …
glucose levels (BGLs). After in vitro enzyme inhibition tests on the dichloromethane extracts …
New 6-nitro-4-substituted quinazoline derivatives targeting epidermal growth factor receptor: design, synthesis and in vitro anticancer studies
AB Farag, AH Othman, MK El-Ashrey… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Twenty compounds of 6-nitro-4-substituted quinazolines were synthesized. Materials &
methods: The new derivatives were evaluated for their epidermal growth factor receptor …
methods: The new derivatives were evaluated for their epidermal growth factor receptor …
Metal catalyst-free β-amination of branched rac-C8N-type such as C7N carbasugars via intramolecular aza-michael addition: Biological evolution, DFT studies and …
In this study, a new stereospecific strategy for the preparation of C 8 N aminocyclohexenols
such as C 7 N, validamine analogs were developed from starting compound 4 via …
such as C 7 N, validamine analogs were developed from starting compound 4 via …
2-Amino-1,3-benzothiazole: Endo N-Alkylation with α-Iodo Methyl Ketones Followed by Cyclization
IA Dorofeev, LV Zhilitskaya, NO Yarosh, BA Shainyan - Molecules, 2023 - mdpi.com
Reactions of 2-amino-1, 3-benzothiazole with aliphatic, aromatic and heteroaromatic α-
iodoketones in the absence of bases or catalysts have been studied. The reaction proceeds …
iodoketones in the absence of bases or catalysts have been studied. The reaction proceeds …