Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

Neurodevelopmental disorders are challenging to study in the laboratory, and despite a
large investment, few novel treatments have been developed in the last decade. While …

Abstract Down syndrome (DS), trisomy 21, is caused by increased dose of genes present on
human chromosome 21 (HSA21). The gene-dose hypothesis argues that a change in the …

Overinhibition is assumed one of the main causes of cognitive deficits (eg memory
impairment) in mouse models of Down syndrome (DS). Yet the mechanisms that drive such …

Objectives Down syndrome (DS) is a genetic condition characterized by cognitive disability
starting from infancy. Children with DS exhibit deficits in several cognitive domains …

While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn
mouse model of Down syndrome (DS), translation to human clinical trials to improve …

Down syndrome (DS), a genetic pathology caused by triplication of chromosome 21, is
characterized by brain hypotrophy and impairment of cognition starting from infancy. While …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

The most distinctive feature of Down syndrome (DS) is moderate to severe cognitive
impairment. Genetic, molecular, and neuronal mechanisms of this complex DS phenotype …

Currently there is no effective therapy available for cognitive impairments in Down syndrome
(DS), one of the most prevalent forms of intellectual disability in humans associated with the …