Epitope landscape in autoimmune neurological disease and beyond
Autoantibody binding has a central role in autoimmune diseases and has also been linked
to cancer, infections, and behavioral disorders. Autoimmune neurological diseases remain …
to cancer, infections, and behavioral disorders. Autoimmune neurological diseases remain …
Application of novel CAR technologies to improve treatment of autoimmune disease
Chimeric antigen receptor (CAR) T cell therapy has become an important treatment for
hematological cancers, and its success has spurred research into CAR T cell therapies for …
hematological cancers, and its success has spurred research into CAR T cell therapies for …
Advances in chimeric antigen receptor T cell therapy for autoimmune and autoinflammatory diseases and their complications
L Zeng, Y Li, W **ang, W **ao, Z Long, L Sun - Journal of Autoimmunity, 2025 - Elsevier
Chimeric antigen receptor T (CAR-T) cells are genetically engineered T cells expressing
transmembrane chimeric antigen receptors with specific targeting abilities. As an emerging …
transmembrane chimeric antigen receptors with specific targeting abilities. As an emerging …
CAR T cells in autoimmune disease: On the road to remission
Several recent reports have demonstrated that B cell-targeting chimeric antigen receptor
(CAR) T cells offer a viable treatment option for patients with autoantibody-mediated …
(CAR) T cells offer a viable treatment option for patients with autoantibody-mediated …
Current and Future Roles of Chimeric Antigen Receptor T-Cell Therapy in Neurology: A Review
FS Ismail, M Gallus, SG Meuth, H Okada… - JAMA …, 2025 - jamanetwork.com
Importance Advancements in molecular engineering have facilitated the creation of
engineered T cells that express synthetic receptors, termedchimeric antigen receptors …
engineered T cells that express synthetic receptors, termedchimeric antigen receptors …
Targeting human plasma cells using regulated BCMA CAR T cells eliminates circulating antibodies in humanized mice
Y Honaker, D Gruber, C Jacobs, RYH Cheng, S Patel… - Molecular Therapy, 2024 - cell.com
Pathogenic long-lived plasma cells (LLPCs) secrete autoreactive antibodies, exacerbating
autoimmune diseases and complicating solid organ transplantation. Targeted elimination of …
autoimmune diseases and complicating solid organ transplantation. Targeted elimination of …
Releasing our model T–chimeric antigen receptor (CAR) T-cells for autoimmune indications
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Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance
Chimeric antigen receptor (CAR) T cells targeting CD19 induce durable responses in B-cell
acute lymphoblastic leukemia (B-ALL). However, the contribution of the tumor …
acute lymphoblastic leukemia (B-ALL). However, the contribution of the tumor …