Metal‐free perovskites (MFPs) possess excellent photophysical properties of perovskites
while avoiding the introduction of toxic metal ions and organic solvents, and have been …

Alkyne hydroamination is an effective approach for the production of enamines and enamine‐
containing N‐heterocycles. However, stereoselectivity control is a considerable challenge in …

A catalyst-free gem-difluorination/spirocyclization reaction has been successfully developed
for the synthesis of gem-difluorinated C2-spiroindoline derivatives from indole-2 …

Palladium-catalyzed fluoroalkylations of aryl halides are valuable reactions for the synthesis
of fluorinated, biologically active molecules. Reductive elimination from an intermediate Pd …

A complex chemical system is often examined based on their fragments, so fragment-based
analysis is the key to chemical understanding. We report the natural fragment bond orbital …

Selective defluorinative functionalization of trifluoromethylarenes (ArCF 3) to obtain the
pharmaceutically common α, α-difluorobenzylic motif is an attractive and elegant synthetic …

Increasing interests of difluorinated amino acids (DFAAs) have been raised in recent years
due to their widespread bio-organic and medical applications. However, to date, only few …

This report describes the Pd-catalyzed decarbonylative coupling of difluorobenzyl
glutarimides with (hetero) aryl boronate esters to yield difluorobenzyl-substituted (hetero) …

We present a metal-free strategy to access fluoroalkyl–olefin linkages from fluoroalkane
precursors and vinyl-pinacol boronic ester (BPin) reagents. This reaction sequence is …

Abstract Pyridine-tetrafluoro-λ6-sulfanyl-alkynes have emerged as building blocks for
synthesizing linearly-linked pyridine-heterocycles. They are prepared via a two-step …