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[HTML][HTML] Phaser. MRage: automated molecular replacement
Phaser. MRage is a molecular-replacement automation framework that implements a full
model-generation workflow and provides several layers of model exploration to the user. It is …
model-generation workflow and provides several layers of model exploration to the user. It is …
Design of protein-binding proteins from the target structure alone
The design of proteins that bind to a specific site on the surface of a target protein using no
information other than the three-dimensional structure of the target remains a challenge …
information other than the three-dimensional structure of the target remains a challenge …
Methods for the refinement of protein structure 3D models
The refinement of predicted 3D protein models is crucial in bringing them closer towards
experimental accuracy for further computational studies. Refinement approaches can be …
experimental accuracy for further computational studies. Refinement approaches can be …
New world bats harbor diverse influenza A viruses
Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature.
The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit …
The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit …
[HTML][HTML] Histone recognition and large-scale structural analysis of the human bromodomain family
Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …
Structural basis for potency and promiscuity in poly (ADP-ribose) polymerase (PARP) and tankyrase inhibitors
Selective inhibitors could help unveil the mechanisms by which inhibition of poly (ADP-
ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 …
ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 …
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
We characterized the mutational landscape of melanoma, the form of skin cancer with the
highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed …
highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed …
Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A)
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
Broadly protective human antibodies that target the active site of influenza virus neuraminidase
Better vaccines against influenza virus are urgently needed to provide broader protection
against diverse strains, subtypes, and types. Such efforts are assisted by the identification of …
against diverse strains, subtypes, and types. Such efforts are assisted by the identification of …
High-resolution protein structure determination by serial femtosecond crystallography
Structure determination of proteins and other macromolecules has historically required the
growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …
growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …